FLOW OF CSF

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 FLOW OF CSF

Cerebrospinal fluid is constantly produced at a secretion rate of 0.2-0.7 ml/min, meaning that there is 600–700 ml of newly produced CSF per day. Since the total volume of CSF averages around 150-270 mL, this means that the entire volume of CSF is replaced around 4 times per day.
The pathway of the cerebrospinal fluid is as follows:
The CSF passes from the lateral ventricles to the third ventricle through the interventricular foramen (of Monro).
From the third ventricle, the CSF flows through the cerebral aqueduct (of Sylvius) to the fourth ventricle.
From the fourth ventricle, some CSF flows through a narrow passage called the obex and enters the central canal of the spinal cord.
However, the majority of CSF passes through the apertures of the fourth ventricle; the median aperture (of Magendie) and two lateral apertures (of Luschka). Via these openings, the CSF enters the cisterna magna and cerebellopontine cisterns, respectively.
From there, the CSF flows through the subarachnoid space of the brain and spinal cord.
It is finally reabsorbed into the dural venous sinuses through arachnoid granulations.


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