Classification of Antipsychotic Drugs
Classification of Antipsychotic Drugs Antipsychotic drugs, also known as neuroleptics or major tranquilizers, are primarily used to treat psychotic disorders such as schizophrenia, bipolar disorder, and other conditions associated with psychosis. These drugs work by altering the activity of neurotransmitters, especially dopamine, in the brain. They are broadly classified into first-generation (typical) and second-generation (atypical) antipsychotics. 1. Pharmacological Classification of Antipsychotic Drugs Antipsychotic drugs can be classified into two main categories based on their mechanism of action, receptor affinity, and side effect profile: First-Generation Antipsychotics (FGAs) or Typical Antipsychotics : These drugs primarily block dopamine (D2) receptors, which alleviates the positive symptoms of psychosis but can also lead to extrapyramidal side effects (EPS). Second-Generation Antipsychotics (SGAs) or Atypical Antipsychotics : These drugs block both dopamine (D2) r...